Immune Profiling and Biomarker Discovery

Biomarker Discovery and Immune Profiling with HuProt™ Arrays

 

Arrayjet Advance™ scientists offers you high quality detection and sensitive profiling for autoantibodies and other novel biomarkers. 

Autoantibodies as biomarkers 

Circulating autoantibodies are powerful resources to aid in the diagnosis and treatment of autoimmune disorders, infectious diseases and cancer - especially with promising advances in immuno-oncology.

Arrayjet Advance profiling with HuProt™ Arrays 

With ~81% of the human proteome on a single slide, the HuProt array represents a more comprehensive and high-throughput alternative to other assay platforms for the development of predictive early diagnostic tests.

HuProt™ benefits for immune profiling 

  • Proteins, not peptides: well-folded with confomationally intact epitopes
  • Largest collection in the world; recently re-sequenced
  • Detect primary (IgM) and secondary (IgG) responses (and other Igs)
  • Rapid and reproducible assay: results and analysis in days, not weeks
  • Low volume of precious sample: as little as 3 μl serum or plasma per assay
  • Economical and customizable: focused arrays can be made based on screening data
  • Access to CDI expert bioinformatics specialists

Biomarker discovery with Arrayjet Advance™ work flow

 

Immune profiling with Arrayjet Advance™ - 2 phased approach

Phase 1: Discovery

Rapidly generate large amounts of data quickly using minimal amounts of serum or plasma. This segment focuses on known disease state sample vs treatment outcome or normal samples and cohort sizes of 50-100 range.

Phase 2: Focus

A focused analysis of a larger number of samples (>200) against recurrent candidates identified during the discovery phase. Arrayjet Advance™ will custom manufacture focused arrays with 50-500 proteins printed in up to 14 miniarrays per slide. This significantly decreases the cost and allows for rapid testing of very large cohorts needed to obtain statistically significant data.

Arrayjet Bioinformatics

Arrayjet expert bioinformatics specialists will analyse your data obtained in the first two phases and - using established bio statistical methods - will determine and identify statistically relevant profiles with potential for diagnostic or predictive tests.

Download brochure for biomarker discovery services

 

Illustrative example of Immune profiling with Arrayjet Advance™