HuProt™ publications

HuProt™ has helped researchers and commercial groups worldwide make important scientific contributions.  A selection of publications is available below.

Identification of serological biomarkers for early diagnosis of lung cancer using a protein array-based approach 
J. Pan, G. Song, D. Chen, Y. Li, S. Liu, S. Hu, C. Rosa, D. Eichinger, I. Pino, H. Zhu, J. Qian, and Y. Huang
Molecular and Cellular Proteomics
Pan et al (2017) - Identification of serological biomarkers for early diagnosis of lung cancer using a protein array-based approach.pdf

A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors
A. Venkataraman, K. Yang, J. Irizarry, M. Mackiewicz, P. Mita, Z. Kuang, L. Xue, D. Ghosh, S. Liu, P. Ramos, S. Hu, D. B. Kain, S. Keegan, R. Saul, S. Colantonio, H. Zhang, F. P. Behn, G. Song, E. Albino, L. Asencio, L. Ramos, L. Lugo, G. Morell, J. Rivera, K. Ruiz, R. Almodovar, L. Nazario, K. Murphy, I. Vargas, Z. A. Rivera-Pacheco, C. Rosa, M. Vargas, J. McDade, B. S Clark, S. Yoo, S. G. Khambadkone, J. de Melo, M. Stevanovic, L. Jiang, Y. Li, W. Y. Yap, B. Jones, A. Tandon, E. Campbell, G. T. Montelione, S. Anderson, R. M. Myers, J. D. Boeke, D. Fenyö, G. Whiteley, J. S. Bader, I. Pino, D. J. Eichinger, H. Zhu, and S. Blackshaw
Nature Methods
Venkataraman et al (2018) - A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors.pdf

High-resolution physicochemical characterization of different intravenous immunoglobulin products
N. Washburn, R. Meccariello, S. Hu, M. Hains, N. Bhatnagar, H. Sarvaiya, B. Kapoor, J. Schaeck, I. Pino, A. Manning, J. C. Lansing, and C. J. Bosques
PLoS One
Washburn et al. (2017) - High-resolution physicochemical characterization of different intravenous Ig products.pdf

Systematic identification of the protein substrates of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T1/T2/T3 using a human proteome microarray
Z. Xu, X .Li, S. Zhou, W. Xie, J. Wang, L. Cheng, S. Wang, S. Guo, Z. Xu, X. Cao, M. Zhang, B. Yu, H. Narimatsu, S. Tao, and Y. Zhang.
Proteomics
Xu et al. (2017) - Systematic identification of the protein substrates of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T1/T2/T3 using a human proteome microarray.pdf

A human proteome array approach to identifying key host proteins targeted by Toxoplasma kinase ROP18
Z. Yang, Y. Hou, T. Hao, H. Rho, J. Wan, Y. Luan, X. Gao, J. Yao, A. Pan, Z. Xie, J. Qian, W. Liao, H. Zhu, and X. Zhou.
Molecular Cell Proteomics
Yang et al. (2017) - A human proteome array approach to identifying key host proteins targeted bu Toxoplasma kinase ROP18.pdf

Evaluation of autoantibody signatures in meningioma patients using human proteome arrays
S. Gupta, S. Mukherjee, P. Syed, N. G. Pandala, S. Choudhary, V. A. Singh, N. Singh, H. Zhu, S. Epari, S. B. Noronha, A. Moiyadi, and Sanjeeva Srivastava
Oncotarget
Gupta et al. (2017) - Evaluation of autoantibody signatures in meningioma patients using human proteome arrays.pdf

Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis
B. K. Chung, B. T. Guevel, G. M. Reynolds, D.B.R.K.Gupta Udatha, E. Kristine, K. Henriksen, Z. Stamataki, G. M. Hirschfield, T. H. Karlsen, and E. Liaskouab
Journal of Autoimmunity
Chung et al (2017) - Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis.pdf

Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor
X. Cheng, Y. Liu, G. Wang, L. Yang, Y. Lu, X. Li, B. Zhou, L. Qu, X. Wang, Y. Cheng, J. Liu, S. Tao, and G. Zhou
Oncotarget
Cheng et al (2017) - Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor.pdf

Global analysis of SUMO-binding proteins identifies SUMOylation as a key regulator of the INO80 chromatin remodeling complex
E. Coxa, W. Hwangd, I. Uzomac, J. Hud, C. M. Guzzoe, J. Jeong, M. J. Matunise, J. Qiand, H. Zhuc, and S. Blackshaw
Molecular and Cellular Proteomics
Cox et al (2017) -Global-analysis-of-sumo-binding-proteins identifies SUMOylation as a key regulator of the INO80 Chromatin Remodeling Complex.pdf

The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states
G. Barry, J. A. Briggs, D. W. Hwang, S. P. Nayler, P. R. J. Fortuna, N. Jonkhout, F. Dachet, J. L. V. Maag, P. Mestdagh, E. M. Singh, L. Avesson, D. C. Kaczorowski, E. Ozturk, N. C. Jones, I. Vetter, L. Arriola-Martinez, J. Hu, G. R. Franco, V. M. Warn, A. Gong, M. E. Dinger, F. Rigo, L. Lipovich, M. J. Morris, T. J. O’Brien, D. S. Lee, J. A. Loeb, S. Blackshaw, J. S. Mattick and E. J. Wolvetang
Nature Scientific Reports
Barry et al (2017) - The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states.pdf

Application of high-throughput protein array in clinical screening for tumor markers.
L. Shi, J. Xi, and B. Zhang.
International Journal of Clinical and Experimental Medicine
Shi et al (2016) - Application of high-throughput protein array in clinical screening for tumor markers.pdf

A new oncofetal biomarker associated with prognosis of lung adenocarcinoma
S. Iyama, M. Ono, H. Kawai-Nakahara, R. E. Husni, T. Dai, T. Shiozawa, A. Sakata, H. Kohrogi, M. Noguchi
Lung Cancer
Iyama et al (2016) - Debrin-A new oncofetal biomarker associated with prognosis of lung adenocarcinoma.pdf

The NIH Protein Capture Reagents Program (PCRP): a standardized protein affinity reagent toolbox
S. Blackshaw, A. Venkataraman, J. Irizarry, K. Yang, S. Anderson, E. Campbell, C. L. Gatlin, N. L. Freeman, R. Basavappa, R. Stewart, M. A. Loss, I. Pino, H. Zhu, and J. S. Bader
Nat Methods
Blackshaw et al (2016) - The NIH protein capture reagents program (PCRP): a standaridized protein affinity reagent toolbox.pdf

Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor
X. Cheng, Y. Liu, G. Wang, L. Yang, Y. Lu, X. Li, B. Zhou, L. Qu, X. Wang, Y. Cheng, J. Liu, S. Tao, and G. Zhou
Oncotarget
Cheng et al (2017) - Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor.pdf

Identification of novel biomarkers for Behcet disease diagnosis using HuProt array approach
C. Hu, J. Pan, G. Song, X. Wen, Z. Wu, S. Chen, W. Xiu Mo, F. Zhang, J. Qian, H. Zhu, and Y. Li
Molecular and Cellular Proteomics
Hu et al (2017) - Identification of novel biomarkers for Behcet disease diagnosis using HuProt array approach.pdf

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
Y. Wang, R. An, G. K. Umanah, H. Park, K. Nambiar, S. M. Eacker, B. Kim, L. Bao, M. M. Harraz, C. Chang, R. Chen, J. E. Wang, T. Kam, J. S. Jeong, Z. Xie, S. Neifert, J. Qian, S. A. Andrabi, S. Blackshaw, H. Zhu, H. Song, G. Ming, V. L. Dawson, and T. M. Dawson
Science
Wang et al (2016) - A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1.pdf

Delineation of autoantibody repertoire through differential proteogenomics in hepatitis C virus-induced cryoglobulinemia
M. Ogishi, H. Yotsuyanagi, K. Moriya, and K. Koike
Nature Scientific Reports
Ogishi et al (2016) - Delineation of autoantibody repertoire through differential proeogenomics in hepatitits C virus-induced cryoglobulinemia.pdf

Penetrance of congenital heart disease in a mouse model of Down Syndrome depends on a trisomic potentiator of a disomic modifier
H. Li, S. Edie, D. Klinedinst, J. S. Jeong, S. Blackshaw, C. L. Maslen, and R. H. Reeves
Genetics
Li et al (2016) - Penetrance of congenital heart disease in a mouse model of Down Syndrome on a trisomic potentiator of a disomic modifier.pdf

Identification of serum biomarkers for gastric cancer diagnosis using a human proteome microarray
L. Yang, J. Wang, J. Li, H. Zhang, S. Guo, M. Yan, Z. Zhu, B. Lan, Y. Ding, M. Xu, W. Li, X. Gu, C. Qi, H. Zhu, Z. Shao, B. Liu, and S. Tao
Molecular and Cellular Proteomics
Yang et al (2016) - Identification of serum biomarkers for gastric cancer diagnosis using a human proteome microarray.pdf

Autoantibody profiling of glioma serum samples to identify biomarkers using human proteome arrays
P. Syed, S. Gupta, S. Choudhary, N. G. Pandala, A. Atak, A. Richharia, Manubhai KP, H. Zhu, S. Epari, S. B. Noronha, A. Moiyadi, and S. Srivastava
Nature Scientific Reports
Syed et al (2016) - Autoantibody profiling of glioma serum samples using human proteome arrays.pdf

Interleukin-1β processing is dependent on a calcium-mediated interaction with calmodulin
J. S. Ainscough, G. F. Gerberick, I. Kimber, and R. J. Dearman
The Journal of Biological Chemistry
Ainscough et al (2015) - Interleukin-1B processing is dependent on a calcium-mediated interaction with Calmodulin.pdf

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
K. Zhang, C. J. Donnelly, A. R. Haeusler, J. C. Grima, J. B. Machamer, P. Steinwald, E. L. Daley, S. J. Miller, K. M. Cunningham, S. Vidensky, S. Gupta, M. A. Thomas, I. Hong, S. Chiu, R. L. Huganir, L. W. Ostrow, M. J. Matunis, J. Wang, R. Sattler, T. E. Lloyd, and J. D. Rothstein
Nature
Zhang et al (2015) - The C9ORF72 repeat expansion disrupts nucleocytoplasmic transport.pdf

Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic
H. Zhang, L. Yang, J. Ling, D. M. Czajkowsky, J. Wang, X. Zhang, Y. Zhou, F. Ge, M. Yang, Q. Xiong, S. Guo, H. Le, S. Wu, W. Yan, B. Liu, H. Zhu, Z. Chen, and S. Tao
PNAS
Zhang et al (2015) - Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic.pdf

Systematic prediction of scaffold proteins reveals new design principles in scaffold-mediated signal transduction
J. Hu, J. Neiswinger, J. Zhang, H. Zhu, and J. Qian
PLoS Computational Biology
Hu et al (2015) - Systematic prediction of scaffold proteins reveals new design principles in scaffold-mediated signal transduction.pdf

Identification of SUMO E3 ligase-specific substrates using the HuProt human proteome microarray
E. Cox, I. Uzoma, C. Guzzo, J. S. Jeong, M. Matunis, S. Blackshaw, and H. Zhu
Methods in Molecular Biology
Cox et al (2015) - Identification of SUMO E3 ligase-specific substrates using the HuProt Human Proteome Array.pdf

Autoantibody profiling on human proteome microarray for biomarker discovery in cerebrospinal fluid and sera of neuropsychiatric Lupus
C. Hu, W. Huang, H. Chen, G. Song, P. Li, Q. Shan, X. Zhang, F. Zhang, H. Zhu, L. Wu, and Y. Li
PLoS One
Hu et al (2015) - Autoantibody profiling on Human Proteome Microarray for biomarker discovery in cerebrospinal fluid and sera of neuropsychiatric lupus.pdf

Characterization of monoclonal antibody's binding kinetics using oblique-incidence reflectivity difference approach
S. Liu, H. Zhang, J. Dai, S. Hu, I. Pino, D. J. Eichinger, H. Lyu, and H. Zhu
mAbs
Liu et al (2015) - Characterization of monoclonal antibody's binding kinetics using oblique-incidence reflectivity difference approach.pdf

Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer
J. Jung, A. Stoeck, B. Guan, R. Wu, H. Zhu, S. Blackshaw, I. Shih, and T. Wang
PLos Genetics
Jung et al (2014) - Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer.pdf

Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. Mol Vis 20:117–124
Q. Fan, L. Huang, X. Zhu, K. Zhang, H. Ye, Y. Luo, X. Sun, P. Zhou, and Y. Lucorresponding
Molecular Vision
Fan et al (2014) - Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.pdf

Global identification of O-GlcNAc Transferase (OGT) interactors by a human proteome microarray and the construction of an OGT interactome
R. Deng, X. He, S. Guo, W. Liu, Y. Tao, and Sheng-Ce Tao
Proteomics
Deng et al (2014) - Global identification of O-GlcNAc transferase (OGT) Interactors by a Human Proteome Microarray and the Construction of an OGT Interactome.pdf

Serine racemase regulated by binding to stargazin and PSD-95: potential NMDA-AMPA glutamate neurotransmission cross-talk
T. M. Ma, B. D. Paul, C. Fu, S. Hu, H. Zhu, S. Blackshaw, H. Wolosker, and S. H. Snyder
Journal of Biological Chemistry
Ma et al (2014) - Serine racemase regulated by binding to stargazin and PSD-95: Potential NMDA-AMPA Glutamate Neurotransmission Cross-talk.pdf

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing
G. Barry, J. A. Briggs, D.P. Vanichkina, E. M. Poth, N. J. Beveridge, V. S. Ratnu, S. P. Nayler, K. Nones, J. Hu, T. W. Bredy, S. Nakagawa, F. Rigo, R. J. Taft, M. J. Cairns, S. Blackshaw, E. J. Wolvetang, and J. S. Mattick
Nature
Barry et al (2013) - The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing.pdf

Protein microarray characterization of the S-nitrosoproteome
Y. Lee, D. Giovinazzo, H. C. Kang, Y. Lee, J. S. Jeong, P. Doulias, Z. Xie, J. Hu, M. Ghasemi, H. Ischiropoulos, J. Qian, H. Zhu, S. Blackshaw, V. L. Dawson, and T. M. Dawsoni
Molecular and Cellular Proteomics
Lee (et al) - 2014 - Protein microarray characterization of the S-nitrosoproteome.pdf

Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity
Y. Chen, L. Yang, L. Cheng, S. Tu, S. Guo, H. Le, Q. Xiong, R. Mo, C. Li, J. Jeong, L. Jiang, S. Blackshaw, L. Bi, H. Zhu, S. Tao, and F. Ge
Mol Cell Proteomics
Chen et al (2013) - Bcl2-associated atanogene 3 interactome analysis reveals a new role in Modulating Proteasome.pdf

RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention
C. J. Donnelly, P. Zhang, J. T. Pham, A. R. Heusler, N. A. Mistry, S. Vidensky, E. L. Daley, E. M. Poth, B. Hoover, D. M. Fines, N. Maragakis, P. J. Tienari, L. Petrucelli, B. J. Traynor, J. Wang, F. Rigo, C. F. Bennett, S. Blackshaw, R. Sattler, and J. D. Rothstein
Neuron
Donelley et al (2013) - RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention.pdf

A human proteome microarray identifies that the heterogeneous nuclear ribonucleoprotein K (hnRNP K) recognizes the 5’ terminal sequence of the hepatitis C virus RNA
B. Fan, K. Lu, F. X. Reymond Sutandy, Y. Chen, K. Konan, H. Zhu, C. C. Kao, and C. Chen
Molecular and Cellular Proteomics
Fan et al (2014) - A human proteome microarray identifies that the heterogenous nuclear ribonuclearprotein K (hnRNP K) recognizes the 5’ terminal sequence of the hepatitis C virus RNA.pdf

Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis
M. K. Tarrant, H. Rho, Z. Xie, Y. L. Jiang, C. Gross, J. C. Culhane, G. Yan, J. Qian, Y. Ichikawa, T. Matsuoka, N. Zachara, F. A. Etzkorn, G. W. Hart, J. S. Jeong, S. Blackshaw, H. Zhu, and P. A. Cole
Nature Chemical Biology
Tarrant et al (2012) - Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis.pdf

Rapid identification of monospecific monoclonal antibodies using a human proteome microarray
J. S. Jeong, L. Jiang, E. Albino, J. Marrero, H. S. Rho, J. Hu, S. Hu, C. Vera, D. Bayron-Poueymiroy, Z. A. Rivera-Pacheco, L. Ramos, C. Torres-Castro, J. Qian, J. Bonaventura, J. D. Boeke, W. Y. Yap, I. Pino, D. J. Eichinger, H. Zhu, and S. Blackshaw
Molecular and Cellular Proteomics
Jeong et al (2012) - Rapid identification on monospecific monoclonal antibodies using a human proteome microarray.pdf

Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance
Y. Huang, J. S. Jeong, J. Okamura, M. Sook-Kim, H. Zhu, R. Guerrero-Preston, and E. A. Ratovitski
Cell Cycle
Huang et al (2012) - Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance.pdf

Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays
C. Hu, G. Song, W. Huang, G. Z. Liu, C. Deng, H. Zeng, L. Wang, F. Zhang, X. Zhang, J. S. Jeong, S. Blackshaw, L. Jiang, H. Zhu, L. Wu, and Y. Li
Molecular and Cellular Proteomics
Hu et al (2012) - Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays.pdf