HuProt™ publications
HuProt™ has helped researchers and commercial groups worldwide make important scientific contributions. A selection of publications is available below.
Cardioprotective mechanism study of salvianic acid A sodium-based on a proteome microarray approach and metabolomic profiling of rat serum after myocardial infarction
D. Jia, L. Xiong, X. Yu, X. Chen, T. Wang, A.lex F. Chen, Y. Chai, Z. Zhu, and C. Zhang
Molecular Omics
A two-way proteome microarray strategy to identify novel Mycobacterium tuberculosis-human interactors
T. Cao1, L. Lyu, H, Jia, J. Wang, F. Du, L. Pan, Z. Li, A. Xing, J. Xiao, Y. Ma, and Z. Zhang
Frontiers in Cellular and Infection Microbiology
Osthole inhibits triple-negative breast cancer cells by suppressing STAT3
X. Dai, C. Yin, Y. Zhang, G. Guo, C. Zhao, O. Wang, Y. Xiang, X. Zhang, and G. Liang
Journal of Experimental and Clinical Cancer Research
Global profiling of PknG interactions using a human proteome microarray reveals novel connections with CypA
F. Wu Y. Liu H. Zhang H. Jiang, Li. Cheng, S. Guo, J. Deng, Li. Bi, X. Zhang, H. Gao, and S. Tao
Proteomics
A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors
A. Venkataraman, K. Yang, J. Irizarry, M. Mackiewicz, P. Mita, Z. Kuang, L. Xue, D. Ghosh, S. Liu, P. Ramos, S. Hu, D. B. Kain, S. Keegan, R. Saul, S. Colantonio, H. Zhang, F. P. Behn, G. Song, E. Albino, L. Asencio, L. Ramos, L. Lugo, G. Morell, J. Rivera, K. Ruiz, R. Almodovar, L. Nazario, K. Murphy, I. Vargas, Z. A. Rivera-Pacheco, C. Rosa, M. Vargas, J. McDade, B. S Clark, S. Yoo, S. G. Khambadkone, J. de Melo, M. Stevanovic, L. Jiang, Y. Li, W. Y. Yap, B. Jones, A. Tandon, E. Campbell, G. T. Montelione, S. Anderson, R. M. Myers, J. D. Boeke, D. Fenyö, G. Whiteley, J. S. Bader, I. Pino, D. J. Eichinger, H. Zhu, and S. Blackshaw
Nature Methods
High-resolution physicochemical characterization of different intravenous immunoglobulin products
N. Washburn, R. Meccariello, S. Hu, M. Hains, N. Bhatnagar, H. Sarvaiya, B. Kapoor, J. Schaeck, I. Pino, A. Manning, J. C. Lansing, and C. J. Bosques
PLoS One
Systematic identification of the protein substrates of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T1/T2/T3 using a human proteome microarray
Z. Xu, X .Li, S. Zhou, W. Xie, J. Wang, L. Cheng, S. Wang, S. Guo, Z. Xu, X. Cao, M. Zhang, B. Yu, H. Narimatsu, S. Tao, and Y. Zhang.
Proteomics
A human proteome array approach to identifying key host proteins targeted by Toxoplasma kinase ROP18
Z. Yang, Y. Hou, T. Hao, H. Rho, J. Wan, Y. Luan, X. Gao, J. Yao, A. Pan, Z. Xie, J. Qian, W. Liao, H. Zhu, and X. Zhou.
Molecular Cell Proteomics
Evaluation of autoantibody signatures in meningioma patients using human proteome arrays
S. Gupta, S. Mukherjee, P. Syed, N. G. Pandala, S. Choudhary, V. A. Singh, N. Singh, H. Zhu, S. Epari, S. B. Noronha, A. Moiyadi, and Sanjeeva Srivastava
Oncotarget
Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis
B. K. Chung, B. T. Guevel, G. M. Reynolds, D.B.R.K.Gupta Udatha, E. Kristine, K. Henriksen, Z. Stamataki, G. M. Hirschfield, T. H. Karlsen, and E. Liaskouab
Journal of Autoimmunity
Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor
X. Cheng, Y. Liu, G. Wang, L. Yang, Y. Lu, X. Li, B. Zhou, L. Qu, X. Wang, Y. Cheng, J. Liu, S. Tao, and G. Zhou
Oncotarget
Global analysis of SUMO-binding proteins identifies SUMOylation as a key regulator of the INO80 chromatin remodelling complex
E. Coxa, W. Hwangd, I. Uzomac, J. Hud, C. M. Guzzoe, J. Jeong, M. J. Matunise, J. Qiand, H. Zhuc, and S. Blackshaw
Molecular and Cellular Proteomics
The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states
G. Barry, J. A. Briggs, D. W. Hwang, S. P. Nayler, P. R. J. Fortuna, N. Jonkhout, F. Dachet, J. L. V. Maag, P. Mestdagh, E. M. Singh, L. Avesson, D. C. Kaczorowski, E. Ozturk, N. C. Jones, I. Vetter, L. Arriola-Martinez, J. Hu, G. R. Franco, V. M. Warn, A. Gong, M. E. Dinger, F. Rigo, L. Lipovich, M. J. Morris, T. J. O’Brien, D. S. Lee, J. A. Loeb, S. Blackshaw, J. S. Mattick and E. J. Wolvetang
Nature Scientific Reports
Application of high-throughput protein array in clinical screening for tumour markers.
L. Shi, J. Xi, and B. Zhang.
International Journal of Clinical and Experimental Medicine
A new oncofetal biomarker associated with prognosis of lung adenocarcinoma
S. Iyama, M. Ono, H. Kawai-Nakahara, R. E. Husni, T. Dai, T. Shiozawa, A. Sakata, H. Kohrogi, M. Noguchi
Lung Cancer
The NIH Protein Capture Reagents Program (PCRP): a standardized protein affinity reagent toolbox
S. Blackshaw, A. Venkataraman, J. Irizarry, K. Yang, S. Anderson, E. Campbell, C. L. Gatlin, N. L. Freeman, R. Basavappa, R. Stewart, M. A. Loss, I. Pino, H. Zhu, and J. S. Bader
Nat Methods
Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor
X. Cheng, Y. Liu, G. Wang, L. Yang, Y. Lu, X. Li, B. Zhou, L. Qu, X. Wang, Y. Cheng, J. Liu, S. Tao, and G. Zhou
Oncotarget
Identification of novel biomarkers for Behcet disease diagnosis using HuProt array approach
C. Hu, J. Pan, G. Song, X. Wen, Z. Wu, S. Chen, W. Xiu Mo, F. Zhang, J. Qian, H. Zhu, and Y. Li
Molecular and Cellular Proteomics
A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
Y. Wang, R. An, G. K. Umanah, H. Park, K. Nambiar, S. M. Eacker, B. Kim, L. Bao, M. M. Harraz, C. Chang, R. Chen, J. E. Wang, T. Kam, J. S. Jeong, Z. Xie, S. Neifert, J. Qian, S. A. Andrabi, S. Blackshaw, H. Zhu, H. Song, G. Ming, V. L. Dawson, and T. M. Dawson
Science
Delineation of autoantibody repertoire through differential proteogenomics in hepatitis C virus-induced cryoglobulinemia
M. Ogishi, H. Yotsuyanagi, K. Moriya, and K. Koike
Nature Scientific Reports
Penetrance of congenital heart disease in a mouse model of Down Syndrome depends on a trisomic potentiator of a disomic modifier
H. Li, S. Edie, D. Klinedinst, J. S. Jeong, S. Blackshaw, C. L. Maslen, and R. H. Reeves
Genetics
Identification of serum biomarkers for gastric cancer diagnosis using a human proteome microarray
L. Yang, J. Wang, J. Li, H. Zhang, S. Guo, M. Yan, Z. Zhu, B. Lan, Y. Ding, M. Xu, W. Li, X. Gu, C. Qi, H. Zhu, Z. Shao, B. Liu, and S. Tao
Molecular and Cellular Proteomics
Autoantibody profiling of glioma serum samples to identify biomarkers using human proteome arrays
P. Syed, S. Gupta, S. Choudhary, N. G. Pandala, A. Atak, A. Richharia, Manubhai KP, H. Zhu, S. Epari, S. B. Noronha, A. Moiyadi, and S. Srivastava
Nature Scientific Reports
Interleukin-1β processing is dependent on a calcium-mediated interaction with calmodulin
J. S. Ainscough, G. F. Gerberick, I. Kimber, and R. J. Dearman
The Journal of Biological Chemistry
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
K. Zhang, C. J. Donnelly, A. R. Haeusler, J. C. Grima, J. B. Machamer, P. Steinwald, E. L. Daley, S. J. Miller, K. M. Cunningham, S. Vidensky, S. Gupta, M. A. Thomas, I. Hong, S. Chiu, R. L. Huganir, L. W. Ostrow, M. J. Matunis, J. Wang, R. Sattler, T. E. Lloyd, and J. D. Rothstein
Nature
Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic.
H. Zhang, L. Yang, J. Ling, D. M. Czajkowsky, J. Wang, X. Zhang, Y. Zhou, F. Ge, M. Yang, Q. Xiong, S. Guo, H. Le, S. Wu, W. Yan, B. Liu, H. Zhu, Z. Chen, and S. Tao
PNAS
Systematic prediction of scaffold proteins reveals new design principles in scaffold-mediated signal transduction
J. Hu, J. Neiswinger, J. Zhang, H. Zhu, and J. Qian
PLoS Computational Biology
Identification of SUMO E3 ligase-specific substrates using the HuProt human proteome microarray
E. Cox, I. Uzoma, C. Guzzo, J. S. Jeong, M. Matunis, S. Blackshaw, and H. Zhu
Methods in Molecular Biology
Autoantibody profiling on human proteome microarray for biomarker discovery in cerebrospinal fluid and sera of neuropsychiatric Lupus
C. Hu, W. Huang, H. Chen, G. Song, P. Li, Q. Shan, X. Zhang, F. Zhang, H. Zhu, L. Wu, and Y. Li
PLoS One
Characterization of monoclonal antibody's binding kinetics using oblique-incidence reflectivity difference approach
S. Liu, H. Zhang, J. Dai, S. Hu, I. Pino, D. J. Eichinger, H. Lyu, and H. Zhu
mAbs
Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer
J. Jung, A. Stoeck, B. Guan, R. Wu, H. Zhu, S. Blackshaw, I. Shih, and T. Wang
PLos Genetics
Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. Mol Vis 20:117–124
Q. Fan, L. Huang, X. Zhu, K. Zhang, H. Ye, Y. Luo, X. Sun, P. Zhou, and Y. Lucorresponding
Molecular Vision
Global identification of O-GlcNAc Transferase (OGT) interactors by a human proteome microarray and the construction of an OGT interactome
R. Deng, X. He, S. Guo, W. Liu, Y. Tao, and Sheng-Ce Tao
Proteomics
Serine racemase regulated by binding to stargazin and PSD-95: potential NMDA-AMPA glutamate neurotransmission cross-talk
T. M. Ma, B. D. Paul, C. Fu, S. Hu, H. Zhu, S. Blackshaw, H. Wolosker, and S. H. Snyder
Journal of Biological Chemistry
The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing
G. Barry, J. A. Briggs, D.P. Vanichkina, E. M. Poth, N. J. Beveridge, V. S. Ratnu, S. P. Nayler, K. Nones, J. Hu, T. W. Bredy, S. Nakagawa, F. Rigo, R. J. Taft, M. J. Cairns, S. Blackshaw, E. J. Wolvetang, and J. S. Mattick
Nature
Protein microarray characterization of the S-nitrosoproteome
Y. Lee, D. Giovinazzo, H. C. Kang, Y. Lee, J. S. Jeong, P. Doulias, Z. Xie, J. Hu, M. Ghasemi, H. Ischiropoulos, J. Qian, H. Zhu, S. Blackshaw, V. L. Dawson, and T. M. Dawsoni
Molecular and Cellular Proteomics
Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity
Y. Chen, L. Yang, L. Cheng, S. Tu, S. Guo, H. Le, Q. Xiong, R. Mo, C. Li, J. Jeong, L. Jiang, S. Blackshaw, L. Bi, H. Zhu, S. Tao, and F. Ge
Mol Cell Proteomics
RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention
C. J. Donnelly, P. Zhang, J. T. Pham, A. R. Heusler, N. A. Mistry, S. Vidensky, E. L. Daley, E. M. Poth, B. Hoover, D. M. Fines, N. Maragakis, P. J. Tienari, L. Petrucelli, B. J. Traynor, J. Wang, F. Rigo, C. F. Bennett, S. Blackshaw, R. Sattler, and J. D. Rothstein
Neuron
A human proteome microarray identifies that the heterogeneous nuclear ribonucleoprotein K (hnRNP K) recognizes the 5’ terminal sequence of the hepatitis C virus RNA
B. Fan, K. Lu, F. X. Reymond Sutandy, Y. Chen, K. Konan, H. Zhu, C. C. Kao, and C. Chen
Molecular and Cellular Proteomics
Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis
M. K. Tarrant, H. Rho, Z. Xie, Y. L. Jiang, C. Gross, J. C. Culhane, G. Yan, J. Qian, Y. Ichikawa, T. Matsuoka, N. Zachara, F. A. Etzkorn, G. W. Hart, J. S. Jeong, S. Blackshaw, H. Zhu, and P. A. Cole
Nature Chemical Biology
Rapid identification of monospecific monoclonal antibodies using a human proteome microarray
J. S. Jeong, L. Jiang, E. Albino, J. Marrero, H. S. Rho, J. Hu, S. Hu, C. Vera, D. Bayron-Poueymiroy, Z. A. Rivera-Pacheco, L. Ramos, C. Torres-Castro, J. Qian, J. Bonaventura, J. D. Boeke, W. Y. Yap, I. Pino, D. J. Eichinger, H. Zhu, and S. Blackshaw
Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance
Y. Huang, J. S. Jeong, J. Okamura, M. Sook-Kim, H. Zhu, R. Guerrero-Preston, and E. A. Ratovitski
Cell Cycle
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays
C. Hu, G. Song, W. Huang, G. Z. Liu, C. Deng, H. Zeng, L. Wang, F. Zhang, X. Zhang, J. S. Jeong, S. Blackshaw, L. Jiang, H. Zhu, L. Wu, and Y. Li
Molecular and Cellular Proteomics