HuProt™ publications

HuProt™ has helped researchers and commercial groups worldwide make important scientific contributions.  A selection of publications is available below.

Global profiling of PknG interactions using a human proteome microarray reveals novel connections with CypA
F. Wu Y. Liu H. Zhang H. Jiang, Li. Cheng, S. Guo, J. Deng, Li. Bi,  X. Zhang, H. Gao, and S. Tao
Proteomics

A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors
A. Venkataraman, K. Yang, J. Irizarry, M. Mackiewicz, P. Mita, Z. Kuang, L. Xue, D. Ghosh, S. Liu, P. Ramos, S. Hu, D. B. Kain, S. Keegan, R. Saul, S. Colantonio, H. Zhang, F. P. Behn, G. Song, E. Albino, L. Asencio, L. Ramos, L. Lugo, G. Morell, J. Rivera, K. Ruiz, R. Almodovar, L. Nazario, K. Murphy, I. Vargas, Z. A. Rivera-Pacheco, C. Rosa, M. Vargas, J. McDade, B. S Clark, S. Yoo, S. G. Khambadkone, J. de Melo, M. Stevanovic, L. Jiang, Y. Li, W. Y. Yap, B. Jones, A. Tandon, E. Campbell, G. T. Montelione, S. Anderson, R. M. Myers, J. D. Boeke, D. Fenyö, G. Whiteley, J. S. Bader, I. Pino, D. J. Eichinger, H. Zhu, and S. Blackshaw
Nature Methods

High-resolution physicochemical characterization of different intravenous immunoglobulin products
N. Washburn, R. Meccariello, S. Hu, M. Hains, N. Bhatnagar, H. Sarvaiya, B. Kapoor, J. Schaeck, I. Pino, A. Manning, J. C. Lansing, and C. J. Bosques
PLoS One

Systematic identification of the protein substrates of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T1/T2/T3 using a human proteome microarray
Z. Xu, X .Li, S. Zhou, W. Xie, J. Wang, L. Cheng, S. Wang, S. Guo, Z. Xu, X. Cao, M. Zhang, B. Yu, H. Narimatsu, S. Tao, and Y. Zhang.
Proteomics

A human proteome array approach to identifying key host proteins targeted by Toxoplasma kinase ROP18
Z. Yang, Y. Hou, T. Hao, H. Rho, J. Wan, Y. Luan, X. Gao, J. Yao, A. Pan, Z. Xie, J. Qian, W. Liao, H. Zhu, and X. Zhou.
Molecular Cell Proteomics

Evaluation of autoantibody signatures in meningioma patients using human proteome arrays
S. Gupta, S. Mukherjee, P. Syed, N. G. Pandala, S. Choudhary, V. A. Singh, N. Singh, H. Zhu, S. Epari, S. B. Noronha, A. Moiyadi, and Sanjeeva Srivastava
Oncotarget

Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis
B. K. Chung, B. T. Guevel, G. M. Reynolds, D.B.R.K.Gupta Udatha, E. Kristine, K. Henriksen, Z. Stamataki, G. M. Hirschfield, T. H. Karlsen, and E. Liaskouab
Journal of Autoimmunity

Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor
X. Cheng, Y. Liu, G. Wang, L. Yang, Y. Lu, X. Li, B. Zhou, L. Qu, X. Wang, Y. Cheng, J. Liu, S. Tao, and G. Zhou
Oncotarget

Global analysis of SUMO-binding proteins identifies SUMOylation as a key regulator of the INO80 chromatin remodeling complex
E. Coxa, W. Hwangd, I. Uzomac, J. Hud, C. M. Guzzoe, J. Jeong, M. J. Matunise, J. Qiand, H. Zhuc, and S. Blackshaw
Molecular and Cellular Proteomics

The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states
G. Barry, J. A. Briggs, D. W. Hwang, S. P. Nayler, P. R. J. Fortuna, N. Jonkhout, F. Dachet, J. L. V. Maag, P. Mestdagh, E. M. Singh, L. Avesson, D. C. Kaczorowski, E. Ozturk, N. C. Jones, I. Vetter, L. Arriola-Martinez, J. Hu, G. R. Franco, V. M. Warn, A. Gong, M. E. Dinger, F. Rigo, L. Lipovich, M. J. Morris, T. J. O’Brien, D. S. Lee, J. A. Loeb, S. Blackshaw, J. S. Mattick and E. J. Wolvetang
Nature Scientific Reports

Application of high-throughput protein array in clinical screening for tumor markers.
L. Shi, J. Xi, and B. Zhang.
International Journal of Clinical and Experimental Medicine

A new oncofetal biomarker associated with prognosis of lung adenocarcinoma
S. Iyama, M. Ono, H. Kawai-Nakahara, R. E. Husni, T. Dai, T. Shiozawa, A. Sakata, H. Kohrogi, M. Noguchi
Lung Cancer

The NIH Protein Capture Reagents Program (PCRP): a standardized protein affinity reagent toolbox
S. Blackshaw, A. Venkataraman, J. Irizarry, K. Yang, S. Anderson, E. Campbell, C. L. Gatlin, N. L. Freeman, R. Basavappa, R. Stewart, M. A. Loss, I. Pino, H. Zhu, and J. S. Bader
Nat Methods

Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor
X. Cheng, Y. Liu, G. Wang, L. Yang, Y. Lu, X. Li, B. Zhou, L. Qu, X. Wang, Y. Cheng, J. Liu, S. Tao, and G. Zhou
Oncotarget

Identification of novel biomarkers for Behcet disease diagnosis using HuProt array approach
C. Hu, J. Pan, G. Song, X. Wen, Z. Wu, S. Chen, W. Xiu Mo, F. Zhang, J. Qian, H. Zhu, and Y. Li
Molecular and Cellular Proteomics

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
Y. Wang, R. An, G. K. Umanah, H. Park, K. Nambiar, S. M. Eacker, B. Kim, L. Bao, M. M. Harraz, C. Chang, R. Chen, J. E. Wang, T. Kam, J. S. Jeong, Z. Xie, S. Neifert, J. Qian, S. A. Andrabi, S. Blackshaw, H. Zhu, H. Song, G. Ming, V. L. Dawson, and T. M. Dawson
Science

Delineation of autoantibody repertoire through differential proteogenomics in hepatitis C virus-induced cryoglobulinemia
M. Ogishi, H. Yotsuyanagi, K. Moriya, and K. Koike
Nature Scientific Reports

Penetrance of congenital heart disease in a mouse model of Down Syndrome depends on a trisomic potentiator of a disomic modifier
H. Li, S. Edie, D. Klinedinst, J. S. Jeong, S. Blackshaw, C. L. Maslen, and R. H. Reeves
Genetics

Identification of serum biomarkers for gastric cancer diagnosis using a human proteome microarray
L. Yang, J. Wang, J. Li, H. Zhang, S. Guo, M. Yan, Z. Zhu, B. Lan, Y. Ding, M. Xu, W. Li, X. Gu, C. Qi, H. Zhu, Z. Shao, B. Liu, and S. Tao
Molecular and Cellular Proteomics

Autoantibody profiling of glioma serum samples to identify biomarkers using human proteome arrays
P. Syed, S. Gupta, S. Choudhary, N. G. Pandala, A. Atak, A. Richharia, Manubhai KP, H. Zhu, S. Epari, S. B. Noronha, A. Moiyadi, and S. Srivastava
Nature Scientific Reports

Interleukin-1β processing is dependent on a calcium-mediated interaction with calmodulin
J. S. Ainscough, G. F. Gerberick, I. Kimber, and R. J. Dearman
The Journal of Biological Chemistry

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
K. Zhang, C. J. Donnelly, A. R. Haeusler, J. C. Grima, J. B. Machamer, P. Steinwald, E. L. Daley, S. J. Miller, K. M. Cunningham, S. Vidensky, S. Gupta, M. A. Thomas, I. Hong, S. Chiu, R. L. Huganir, L. W. Ostrow, M. J. Matunis, J. Wang, R. Sattler, T. E. Lloyd, and J. D. Rothstein
Nature

Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic
H. Zhang, L. Yang, J. Ling, D. M. Czajkowsky, J. Wang, X. Zhang, Y. Zhou, F. Ge, M. Yang, Q. Xiong, S. Guo, H. Le, S. Wu, W. Yan, B. Liu, H. Zhu, Z. Chen, and S. Tao
PNAS

Systematic prediction of scaffold proteins reveals new design principles in scaffold-mediated signal transduction
J. Hu, J. Neiswinger, J. Zhang, H. Zhu, and J. Qian
PLoS Computational Biology

Identification of SUMO E3 ligase-specific substrates using the HuProt human proteome microarray
E. Cox, I. Uzoma, C. Guzzo, J. S. Jeong, M. Matunis, S. Blackshaw, and H. Zhu
Methods in Molecular Biology

Autoantibody profiling on human proteome microarray for biomarker discovery in cerebrospinal fluid and sera of neuropsychiatric Lupus
C. Hu, W. Huang, H. Chen, G. Song, P. Li, Q. Shan, X. Zhang, F. Zhang, H. Zhu, L. Wu, and Y. Li
PLoS One

Characterization of monoclonal antibody's binding kinetics using oblique-incidence reflectivity difference approach
S. Liu, H. Zhang, J. Dai, S. Hu, I. Pino, D. J. Eichinger, H. Lyu, and H. Zhu
mAbs

Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer
J. Jung, A. Stoeck, B. Guan, R. Wu, H. Zhu, S. Blackshaw, I. Shih, and T. Wang
PLos Genetics

Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. Mol Vis 20:117–124
Q. Fan, L. Huang, X. Zhu, K. Zhang, H. Ye, Y. Luo, X. Sun, P. Zhou, and Y. Lucorresponding
Molecular Vision

Global identification of O-GlcNAc Transferase (OGT) interactors by a human proteome microarray and the construction of an OGT interactome
R. Deng, X. He, S. Guo, W. Liu, Y. Tao, and Sheng-Ce Tao
Proteomics

Serine racemase regulated by binding to stargazin and PSD-95: potential NMDA-AMPA glutamate neurotransmission cross-talk
T. M. Ma, B. D. Paul, C. Fu, S. Hu, H. Zhu, S. Blackshaw, H. Wolosker, and S. H. Snyder
Journal of Biological Chemistry

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing
G. Barry, J. A. Briggs, D.P. Vanichkina, E. M. Poth, N. J. Beveridge, V. S. Ratnu, S. P. Nayler, K. Nones, J. Hu, T. W. Bredy, S. Nakagawa, F. Rigo, R. J. Taft, M. J. Cairns, S. Blackshaw, E. J. Wolvetang, and J. S. Mattick
Nature

Protein microarray characterization of the S-nitrosoproteome
Y. Lee, D. Giovinazzo, H. C. Kang, Y. Lee, J. S. Jeong, P. Doulias, Z. Xie, J. Hu, M. Ghasemi, H. Ischiropoulos, J. Qian, H. Zhu, S. Blackshaw, V. L. Dawson, and T. M. Dawsoni
Molecular and Cellular Proteomics

Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity
Y. Chen, L. Yang, L. Cheng, S. Tu, S. Guo, H. Le, Q. Xiong, R. Mo, C. Li, J. Jeong, L. Jiang, S. Blackshaw, L. Bi, H. Zhu, S. Tao, and F. Ge
Mol Cell Proteomics

RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention
C. J. Donnelly, P. Zhang, J. T. Pham, A. R. Heusler, N. A. Mistry, S. Vidensky, E. L. Daley, E. M. Poth, B. Hoover, D. M. Fines, N. Maragakis, P. J. Tienari, L. Petrucelli, B. J. Traynor, J. Wang, F. Rigo, C. F. Bennett, S. Blackshaw, R. Sattler, and J. D. Rothstein
Neuron

A human proteome microarray identifies that the heterogeneous nuclear ribonucleoprotein K (hnRNP K) recognizes the 5’ terminal sequence of the hepatitis C virus RNA
B. Fan, K. Lu, F. X. Reymond Sutandy, Y. Chen, K. Konan, H. Zhu, C. C. Kao, and C. Chen
Molecular and Cellular Proteomics

Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis
M. K. Tarrant, H. Rho, Z. Xie, Y. L. Jiang, C. Gross, J. C. Culhane, G. Yan, J. Qian, Y. Ichikawa, T. Matsuoka, N. Zachara, F. A. Etzkorn, G. W. Hart, J. S. Jeong, S. Blackshaw, H. Zhu, and P. A. Cole
Nature Chemical Biology

Rapid identification of monospecific monoclonal antibodies using a human proteome microarray
J. S. Jeong, L. Jiang, E. Albino, J. Marrero, H. S. Rho, J. Hu, S. Hu, C. Vera, D. Bayron-Poueymiroy, Z. A. Rivera-Pacheco, L. Ramos, C. Torres-Castro, J. Qian, J. Bonaventura, J. D. Boeke, W. Y. Yap, I. Pino, D. J. Eichinger, H. Zhu, and S. Blackshaw

Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance
Y. Huang, J. S. Jeong, J. Okamura, M. Sook-Kim, H. Zhu, R. Guerrero-Preston, and E. A. Ratovitski
Cell Cycle

Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays
C. Hu, G. Song, W. Huang, G. Z. Liu, C. Deng, H. Zeng, L. Wang, F. Zhang, X. Zhang, J. S. Jeong, S. Blackshaw, L. Jiang, H. Zhu, L. Wu, and Y. Li
Molecular and Cellular Proteomics