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Microarray printing technology from Arrayjet enhances high-throughput analysis of bio-molecules using infrared spectroscopy at Universite Libre de Bruxelles (ULB)

  • Posted: 13/07/15

Arrayjet’s Marathon microarray instrument now makes it possible to quickly perform high throughput analysis of the infrared spectrum of bio molecules at the Free University of Brussels (Université Libre de Bruxelles, ULB). The Center for Structural Biology and Bioinformatics (ULB) installed the Arrayjet Marathon Classic in April this year.

ULB’s method is based on focal plane array technology that detects and records tens of thousands of spectra simultaneously. For proteins, less than one picogram is required to collect high quality spectra by deploying infrared imaging technology. This brings invaluable information on the protein structure, glycosylation, phosphorylation, lipid or detergent content in a single spectrum. High throughput analysis of biomolecules at ULB will be accelerated by the use of Arrayjet’s non-contact inkjet microarray technology and infrared imaging technique.

One of the first projects at ULB, implementing a combination of the robust Marathon microarrayer and infrared imaging is ROBOTEIN. A Belgian inter-University action aimed at providing industrial partners with a platform to produce, purify and test the structure and function of proteins. These are high throughput quality control of proteins experiencing a wide variety of processes and environments. The second project is MIRSEC, an initiative to create a spin off active in the field of protein quality control by infrared spectroscopy. This includes protein quantification, protein structure, quantification of protein phosphorylations and glycosylations, quantification of other molecules such as lipids and detergents. All parameters are obtained from a single spectrum by chemometric methods.

Professor Erik Goormaghtigh, Head of Structure and Function of Biological Membrane at the Centre of Structural Biology and Bioinformatics explains the benefits to using Arrayjet’s non contact microarray spotter in this field. "The Marathon instrument from Arrayjet was selected for the quality of the spotting, the small size of the spots (50-60 µm) on various substrates as observed in preliminary tests and because it is provided with a dust-free chamber that is temperature and humidity controlled, we also found it to be very competitive cost."Russell Brown, European Sales Executive, Arrayjet adds; Université Libre de Bruxelles, ULB has become a leader in the analysis of biological molecules by infrared spectroscopy. We are very pleased that ULB has selected Arrayjet technology for its research projects. ULB have chosen our high throughput Marathon Classic Microarrayer for its printing and I am confident that this decision will pay off for the SMCB laboratory.”

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