Arrayjet Microarray Case Studies
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Customer case studies
Arrayjet scientists enjoy working with customers to produce case studies that support interest in their research and generate further collaboration opportunities.
CDI Laboratories: the largest Human Proteome Array (HuProt™)
CDI was using an old pin-spotter and experiencing frequent production delays, loss-of-yield, batch inconsistency and sample waste.
Arrayjet helped CDI transfer to non-contact inkjet printing so their arrays could be printed in reproducible batches of 1000 slides. HuProt™ is now commercially available, with 81% of the human proteome on a single glass slide.
Screening services are available through Arrayjet Advance™ and support the following applications:
- Antibody specificity
- DNA/RNA binding
- Autoimmune profiling
- Enzyme substrate identification
- Small molecule profiling
- Protein-protein interaction
KEMRI Wellcome Trust researchers transferred from ELISA to microarray and increased productivity by 99%
Researchers at KEMRI Wellcome Trust (Kilifi, Kenya) outsourced printing to Arrayjet Advance experts who printed 1000 slides, enabling the team to profile >20,000 patient samples in the largest malaria study of its kind.
Read about how researchers transferred from ELISA to microarray technology here: Vaccine target identification
In situ protein synthesis: cost-effective and reproducible cell-free arrays
Nucleic Acid Programmable Protein Arrays (NAPPA) offer a cost-effective and highly reproducible solution to cancer and autoimmune researchers involved in biomarker profiling and drug discovery.
Manuel Fuentes' team at the Cancer Investigation Centre (Salamanca, Spain) swapped their Genetix pin-spotter for Arrayjet inkjet technology and now benefit from:
- Tenfold reduction in sample use
- Fivefold increase in array production
- Fourfold increase in speed
Read the NAPPA story here: In situ protein synthesis: cost-effective and reproducible cell-free arrays
EMBL Monoclonal Antibody Core Facility adopts high throughput hybridoma screening method
By consistently producing reliable, high quality microarrays, Arrayjet technology is assisting hybridoma screening programmes and antibody validation services, worldwide.
Prior to transferring to the Arrayjet platform, the Monoclonal Antibody Core Facility (MACF) at the European Molecular Biology Laboratory were screening hybridomas using ELISA, severely limiting the number of fusions that could be assayed per week. By transferring their technology, the MACF benefitted from:
- Threefold reduction in weekly sample and slide costs
- Automated print run, enabling staff remained available for other projects
- Speed enabled eight hybridoma fusions to be screened every week
Read their story here: High throughput hybridoma screening by microarray: case study
Inkjet printing for the production of protein microarrays
The ability of Arrayjet technology to print viscous samples in viscous cryoprotectant solutions such as glycerol or ethylene glycol is a distinct advantage. That the print head never comes into contact with the slides is essential for printing protein microarrays on delicate nitrocellulose or hydrogel surfaces.
In providing the most high throughput technology, Arrayjet enable researchers to quickly produce multiplex arrays for commercial screening, validation or diagnostic purposes.
Read Arrayjet's peer-reviewed article here: Inkjet printing for the production of protein microarrays