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Protein Microarrays for Systematical Deciphering of SARS-CoV-2 Specific Humoral Immune Responses
Arrayjet welcomed Sheng-ce Tao from Shanghai Jiao Tong University. The Tao Lab have constructed a SARS-CoV-2 protein microarray and analysed the antibody responses of >1000 COVID-19 patients. They generated a comprehensive antibody response (IgG and IgM) landscape and have identified potential biomarkers for predicting the severity and outcome of the patients.
Furthermore, this landscape will facilitate our understanding of SARS-CoV-2-specific humoral responses and might be useful for vaccine refinement.
Multi-pronged functional proteomics approaches for biomarker discovery in chronic and infectious diseases
Arrayjet welcomed Manuel Fuentes from Centro de Investigación del Cáncer (IBMCC-FICUS) to discuss how protein microarrays are proving crucial in biomarker discovery. Manuel was joined by Angela-Patricia Hernandez, Pablo Juanes-Velasco, and Alicia Landeira-Viñuela.
The team has extensive experience in developing protein microarrays in many formats and with different samples in order to deepen the understanding of biomarkers in chronic illness, cancer, and infectious disease.
Carbohydrate Microarray and Novel Glycoprofiling Applications
Combining the high-throughput capacity of carbohydrate microarray with the specificity of monoclonal antibodies has potential across many applications.
William George Tycho Willats from N8 AgriFood, and Silvia Vidal Melgosa from Max Planck Institute for Marine Microbiology, demonstrated ways to determine substrate specificity of carbohydrate-active enzymes, and how the same principle can be used to screen other enzymes types, such as proteases.
Seromics: Decoding the Antibody Fingerprint
Each individual carries a 'fingerprint' of antibodies that describes a lifetime of immune experiences to foods, allergens, viruses, the microbiome, and other exposures. This fingerprint is exceptionally unique to each individual and can remain stable for decades - but what does it mean?
In this talk, CDI's director of Biomarker Development Tyler Hulett, PhD, will discuss the potential importance of anti-viral and autoantibody seromics technologies - what we already know about the antibody fingerprint - and what we still don't know - using example data from SARS-CoV-2, cancer, and autoimmune patients.
High-Density Protein Arrays and Affinity Proteomics
Arrayjet welcomes Ronald Sjöberg and August Jernbom Falk from the KTH affinity proteomics group at the SciLifeLab in Stockholm to discuss the high-density protein array developed by the Peter Nilsson group.
Ronald heads up the Autoimmunity Profiling facility and supported by the Human Protein Atlas offers proteome-wide screening for autoantibody reactivity, epitope mapping, and antibody validation.
August talks about autoantibody profiling in psychiatric disorders.