Drug Target Discovery (antigen discovery)
In this section
- Antibody specificity and characterisation
- Biomarker discovery
- Drug Target Discovery (Antigen discovery)
- Epitope mapping
- Gene expression profiling
- Human glycomics
- Plant glycomics
- Hybridoma screening
- Label-free (e.g. SPRi)
- Point of care diagnostics
- Reverse phase protein arrays (RPPA)
- Single cell analysis
- Small Molecule Screening
Drug Target Discovery (Antigen discovery)
Identifying antigenic targets for vaccines using traditional methods can be time-consuming. Protein microarray is a multiplex alternative that offers significant advantages in throughput, enabling researchers to simplify screening experiments, and speed up the discovery of antigenic vaccine targets.
Watch Prof. Faith Osier talk at TED2018 about how Arrayjet's custom protein printing service helped her team to profile 10,000 human serum samples to identify antibodies against the malaria parasite, Plasmodium falciparum: The key to a better malaria vaccine
Reproducible printing is crucial to producing reliable protein arrays. Arrayjet's application note demonstrates printing consistency using a Marathon microarray spotter.
KEMRI Wellcome Trust researchers utilised Arrayjet's Ultra Marathon II microarrayer and printed 1000 slides to conduct the largest malaria study of its kind - something that wouldn't have been possible using ELISA methods.
KILchip v1.0: A novel Plasmodium falciparum merozoite protein microarray to facilitate malaria vaccine candidate prioritization
G. Kamuyu, J. Tuju, R. Kimathi, K. Mwai, J. Mburu, N. Kibinge, M. Chong Kwan, S. Hawkings, R. Yaa, E. Chepsat, J. M. Njunge, T. Chege, F. Guleid, M. Rosenkranz, C. K. Kariuki, R. Frank, S. M. Kinyanjui, L. M. Murungi, P. Bejon, A. Färnert, K. K. A. Tetteh, J. G. Beeson, D. J. Conway, K. Marsh, J. C. Rayner and F. H. A. Osier
Frontiers in Immunology
Retrospective identification of a broad IgG repertoire differentiating patients with S. aureus skin and soft tissue infections from controls
F. Rigat, E. Bartolini, M. Dalsass, N. Kumar, S. Marchi, P. Speziale, D. Maione, L. Chen, M. R. Romano, M. Alegre, F. Bagnoli, R. S. Daum, and M. Z. David
Frontiers in Immunology
"The combination of an excellent product in their microarray printers and a responsive technical support team to assist with bespoke solutions to individual project needs were two of the many attributes that attracted us to work with Arrayjet. At every step of the design of an in-house microarray chip, we had at our disposal a dedicated team of application specialists who were very cordial and available to respond to our many queries. It was on the back of this excellent support that we eventually purchased one of their microarray printers and we have continued to enjoy excellent technical training on the instrument and engineering support."
Dr James Tuju, Principal Investigator, KEMRI Wellcome Trust, Kenya