Compound library screening

Small molecule microarray for compound library screening

Screening compounds for hit identification is the first stage of small molecules drug discovery.  Compound libraries can range from tens of thousands to billions of unique molecules and as such, methods for rapid compound library screening are in high demand by the pharmaceutical industry.

High-throughput screening has been pivotal to drug discovery but requires expensive equipment.  Small molecule arrays offer a cost-effective solution for ligand discovery and are being utilised by academics and pharma groups worldwide.

 

 

Selected publications

High-resolution crystal structures of the D1 and D2 domains of protein tyrosine phosphatase epsilon for structure-based drug design
G. T. Lountos, S. Raran-Kurussi, B. M. Zhao, B. K. Dyas, T. R. Burke Jr, R. G. Ulrich and D. S. Waugh
Structural Biology

Targeting protein-protein interactions of tyrosine phosphatases with microarrayed fragment libraries displayed on phosphopeptide substrate scaffolds
M. Hogan, M. Bahta, K. Tsuji, T. X. Nguyen, S. Cherry, G. T. Lountos, J. E. Tropea, B. M. Zhao, X. Z. Zhao, D. S. Waugh, T. R. Burke, Jr., and R. G. Ulrich
ACS Combinatorial Science