Epitope mapping

Epitope mapping

Epitopes are the binding sites of antibodies, and characterisation can aid in the discovery and design of novel therapeutic drugs and vaccines.

By elucidating the mechanism of action, epitope mapping methods can assist the development of monoclonal antibodies.  Peptide arrays are therefore a useful tool for high-throughput monoclonal antibody screening.

 

 

Selected publications

Epitope mapping of a monoclonal antibody directed against Neisserial heparin binding antigen using next generation sequencing of antigen-specific libraries
M. Domina, V. L. Cariccio, S. Benfatto, M. Venza, I. Venza, D. Donnarumma, E. Bartolini, E. Borgogni, M. Bruttini, L. Santini, A. Midiri, R. Galbo, L. Romeo, F. Patanè, C. Biondo, N. Norais, V. Masignani, G. Teti , F. Felici, and C. Beninati
PLoS ONE

Human protective response induced by meningococcus B vaccine is mediated by the synergy of multiple bactericidal epitopes
M. Giuliani, E. Bartolini, B. Galli, L. Santini, P. Lo Surdo, F. Buricchi, M. Bruttini, B. Benucci, N. Pacchiani, L. Alleri, D. Donnarumma, W. Pansegrau, I. Peschiera, I. Ferlenghi, R. Cozzi, N. Norais, M. M. Giuliani, D. Maione, M. Pizza, R. Rappuoli, O. Finco, and V. Masignani
Nature Scientific Reports

Phage display revisited: Epitope mapping of a monoclonal antibody directed against Neisseria meningitidis adhesin A using the PROFILER technology
V. L. Cariccio, M. Domina, S. Benfatto, M. Venza, I. Venza, A. Faleri, M. Bruttini, E. Bartolini, M. M. Giuliani, L. Santini, B. Brunelli, N. Norais, E. Borgogni, A. Midiri, R. Galbo, L. Romeo, C. Biondo, V. Masignani, G. Teti, F. Felici, and C. Beninati
mAbs

 

Testimonials

"We are glad to have found a dedicated partner that accepted the specific challenges of our regulated production environment and developed an instrument tailored to our needs.”

Dr. Dr Holger Wenschuh, CEO, JPT Peptide Technologies