Human glycomics

Human glycomics

Glycans and complementary glycan-binding proteins perform a variety of functions relating to cell-cell interactions, viral recognition, modulation of cell function, cancer development and tumour metastasis.

Lectin and antibody microarrays are a key tool for high-throughput biomarker discovery and immune response profiling against glycoconjugate vaccines.  When combined with Arrayjet technology, the potential exists to study up to 75,000 interactions on a single microarray slide.

 

Selected publications

Deciphering how Cpl-7 cell wall-binding repeats recognize the bacterial peptidoglycan
Noemí Bustamante, Manuel Iglesias-Bexiga, Noelia Bernardo-García, Noella Silva-Martín, Guadalupe García, María A. Campanero-Rhodes, Esther García, Isabel Usón, Rubén M. Buey, Pedro García, Juan A. Hermoso, Marta Bruix and Margarita Menéndez
Nature Scientific Reports

Lectin activity of the pneumococcal pillin proteins
C. J. Day, A. W. Paton, R. M. Harvey, L. E. Hartley-Tassell, K. L. Seib, J. Tiralongo, N. Bovin, S. Savino, V. Masignani, J. C. Paton, and M. P. Jennings
Nature Scientific Reports